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Hahnemann found that the provers’ responses varied, some showed a few mild symptoms in response to a substance, while others experienced vigorous reactions with a variety of symptoms. The symptoms that were most commonly found for each substance he called first line, or keynote symptoms. Second line symptoms were less common and third line symptoms were rare or idiosyncratic. The combination of symptoms made up a “drug picture” for each substance being tested.

Hahnemann continued to carry out his experiments and provings, testing a wide range of natural sources. He had rediscovered the principle of “like can cure like” and his work would bring about the establishment of a new system of medicine.